What is PrEP?

PrEP, or pre-exposure prophylaxis, is a daily pill to help keep you HIV-negative. When taken as prescribed, PrEP is highly effective. PrEP is safe and generally well tolerated. Most insurance plans (public and private) cover PrEP.

Common PrEP Questions

How effective is PrEP?

PrEP is very effective at preventing HIV infection. When used every day, it reduces the risk of HIV infection by up to 99%. When combined with other HIV prevention strategies, like condoms or treatment as prevention, there is even greater protection.

PrEP does not protect against sexually transmitted infections including gonorrhea, syphilis or chlamydia.

Learn more about PrEP at prepfacts.org.

Is PrEP right for me?

PrEP may not be for everyone, but it could be for you.

If you have questions about whether PrEP might be for you, click on the chat button in the bottom right hand corner of this page or call Andy at Partnership Health Center (406) 258-4418.

Also, the Los Angeles LGBT Center has developed a tool that can help you determine if PrEP is right for you. Check out their tool here:

Where can I find a PrEP provider?

Depending on your location, we can refer you to a provider that can prescribe PrEP.

If you have questions about where to find a PrEP provider in your area, click on the chat button in the bottom right hand corner of this page or call Andy at Partnership Health Center (406) 258-4418.

How do I pay for PrEP?

Most insurance providers cover the cost of PrEP, but if you are underinsured or lack health insurance we can help get you on a qualifying plan that can help cover the cost of medication and follow-up appointments. Important: If you have insurance, we strongly encourage you to contact your insurance provider to check if they cover Truvada for PrEP.

What if my insurance does not cover PrEP?

The Gilead Medication Assistance Program may be able to determine if you are qualified to receive Truvada for PrEP free of charge. We can help you with the enrollment process.

How do I take PrEP?

If you have questions about how to take PrEP, click on the chat button in the bottom right hand corner of this page or call Andy at Partnership Health Center (406) 258-4418.

There are generally two ways providers can prescribe PrEP:

1 pill, once a day, every day

We recommend choosing a consistent time of day to take PrEP that works with your schedule. Factor in decisions like:

"When will I be eating?"
PrEP can be taken with or without food.

"When will I be brushing my teeth?"
This is a great way to work PrEP into your daily schedule.These are a couple of ways that people have worked PrEP into their daily routine. Finding a routine that works for you helps keep you PrEP'd and on track!


PrEP can be taken on-demand through a routine commonly referred to as "2-1-1".

The "2-1-1" regimen is recommended only for people having anal sex.

For example:

Situation A
"I know when I am going to have sex tonight, how do I use 2-1-1?"

2 pills 2-24 hours before sex
1 pill 24 hours after your first dose
1 pill 48 hours after your first dose

Source: i-BASE


Situation B
"I started 2-1-1, and I plan to hookup several times this week."

Source: i-BASE


For any clarification or questions on other scenarios or the 2-1-1 process, please tap the chat button at the bottom right-hand corner of the page.

Which way of taking PrEP is right for me?

First, consistent adherence to either method is important. That means if you are on the one-a-day, regimen, you must take PrEP every day. If you are on the 2-1-1 regimen, you must adhere to the 2-1-1 method. It is important to not skip any doses on either regimen.

PrEP in either method only works when taken as prescribed.

One a day or 2-1-1?

A rule of thumb is that daily PrEP may be for people who hookup often, but who may not know when it's going to happen. 2-1-1 PrEP may be for people who know when they are going to hookup and know what type of sex they are going to have.


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